The mechanism of inhibition by H2 of H2-evolution by hydrogenases

Fourmond V, Baffert C, Sybirna K, Dementin S, Abou-Hamdan A, Meynial-Salles I, Soucaille P, Bottin H, Léger C.

Chem Commun (Camb). 2013 Aug 7;49(61):6840-2. doi: 10.1039/c3cc43297a. Epub 2013 Jun 24

By analysing the results of experiments carried out with two FeFe hydrogenases and several “channel mutants” of a NiFe hydrogenase, we demonstrate that whether or not hydrogen evolution is significantly inhibited by H2 is not a consequence of active site chemistry, but rather relates to H2 transport within the enzyme.

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